Selected Publications


Pocivavsek A, Elmer GI, Schwarcz R. (2019) Inhibition of kynurenine aminotransferase II attenuates hippocampus-dependent memory deficit in adult rats treated prenatally with kynurenine. Hippocampus. 29(2):73-77.


Baratta A.M., Viechweg S.S., Mong J.A., Pocivavsek A. (2018) A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats. J Vis Exp. 19;(138).

Notarangelo F.M., Pocivavsek A., Schwarcz R. (2018) Exercise Your Kynurenines to Fight Depression. Trends Neurosci. 41(8):491-493.

Chiappelli J., Rowland L.M., Notarangelo F.M., Wijtenburg S.A., Thomas M.A.R., Pocivavsek A., Jones A., Wisner K., Kochunov P., Schwarcz R., Hong L.E. (2018) Salivary kynurenic acid response to psychological stress: inverse relationship to cortical glutamate in schizophrenia. Neuropsychopharmacology. 43(8):1706-1711.

Baratta, A.M., Buck, S.A., Buchla, A.D., Fabian, C.B., Chen, S., Mong, J.A., & Pocivavsek, A. (2018) Sex Differences in Hippocampal Memory and Kynurenic Acid Formation Following Acute Sleep Deprivation in Rats. Scientific Reports, 8(1):6963.


Pocivavsek, A., & Rowland, L. M. (2017). Basic Neuroscience Illuminates Causal Relationship between Sleep and Memory: Translating to Schizophrenia. Schizophrenia Bulletin44(1), 7-14

Pocivavsek, A., Baratta, A. M., Mong, J. A., & Viechweg, S. S. (2017). Acute Kynurenine Challenge Disrupts Sleep–Wake Architecture and Impairs Contextual Memory in Adult Rats. Sleep40(11), zsx141.

Hahn, B., Reneski, C. H., Pocivavsek, A., & Schwarcz, R. (2017). Prenatal kynurenine treatment in rats causes schizophrenia-like broad monitoring deficits in adulthood. Psychopharmacology, 1-11.

Erhardt, S., Pocivavsek, A., Repici, M., Liu, X. C., Imbeault, S., Maddison, D. C., ... & Giorgini, F. (2017). Adaptive and behavioral changes in kynurenine 3-monooxygenase knockout mice: relevance to psychotic disorders. Biological Psychiatry82(10), 756-765.

Notarangelo, F. M., & Pocivavsek, A. (2017). Elevated kynurenine pathway metabolism during neurodevelopment: implications for brain and behavior. Neuropharmacology112, 275-285.


Clark, S. M., Pocivavsek, A., Nicholson, J. D., Notarangelo, F. M., Langenberg, P., McMahon, R. P., ... & Schwarcz, R. (2016). Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals. Journal of Psychiatry & Neuroscience: JPN41(6), 386.

Pershing, M. L., Phenis, D., Valentini, V., Pocivavsek, A., Lindquist, D. H., Schwarcz, R., & Bruno, J. P. (2016). Prenatal kynurenine exposure in rats: age-dependent changes in NMDA receptor expression and conditioned fear responding. Psychopharmacology233(21-22), 3725-3735.


Pershing, M. L., Bortz, D. M., Pocivavsek, A., Fredericks, P. J., Jørgensen, C. V., Vunck, S. A., ... & Bruno, J. P. (2015). Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: implications for schizophrenia. Neuropharmacology90, 33-41.


Pocivavsek, A., Thomas, M. A., Elmer, G. I., Bruno, J. P., & Schwarcz, R. (2014). Continuous kynurenine administration during the prenatal period, but not during adolescence, causes learning and memory deficits in adult rats. Psychopharmacology231(14), 2799-2809.

Chiappelli, J., Pocivavsek, A., Nugent, K. L., Notarangelo, F. M., Kochunov, P., Rowland, L. M., ... & Hong, L. E. (2014). Stress-induced increase in kynurenic acid as a potential biomarker for patients with schizophrenia and distress intolerance. JAMA Psychiatry71(7), 761-768.

Wu, H. Q., Okuyama, M., Kajii, Y., Pocivavsek, A., Bruno, J. P., & Schwarcz, R. (2014). Targeting kynurenine aminotransferase II in psychiatric diseases: promising effects of an orally active enzyme inhibitor. Schizophrenia Bulletin40(Suppl_2), S152-S158.


Alexander, K. S., Pocivavsek, A., Wu, H. Q., Pershing, M. L., Schwarcz, R., & Bruno, J. P. (2013). Early developmental elevations of brain kynurenic acid impair cognitive flexibility in adults: reversal with galantamine. Neuroscience238, 19-28.


Pocivavsek, A., Wu, H. Q., Elmer, G. I., Bruno, J. P., & Schwarcz, R. (2012). Pre‐and postnatal exposure to kynurenine causes cognitive deficits in adulthood. European Journal of Neuroscience35(10), 1605-1612.


Pocivavsek, A., Wu, H. Q., Potter, M. C., Elmer, G. I., Pellicciari, R., & Schwarcz, R. (2011). Fluctuations in endogenous kynurenic acid control hippocampal glutamate and memory. Neuropsychopharmacology36(11), 2357.

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